There have been some interesting Pokemon fan projects over the years, but Pokemon Uranium is certainly one of the more unique efforts.
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The game, covered today by Kotaku, has been in development for six years as a fan passion project made in RPGMaker XP, and is currently in its forth public beta according to the official website. Pokemon Uranium is based on a new Nuclear type, caused by radiation seeping from power plants. Here's the description:
"Nuclear-type Pokemon are feral, corrupt versions of ordinary Pokemon, who won't listen to a trainer but will attack anything in sight with destructive force. The only way to beat them is to attack them fast and quick, because Nuclear-type is unstable: in exchange for being super-effective on every other type, it is also weak to every other type."
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Sounds interesting, right? It's combined with a unique region, Tandor, and new characters and features. Among those are the Pokemon Speech Translator, which allows communication with humans, and Nuzlocke Mode, which is based on a popular user-created challenge that players have imposed on themselves for years to make the games more difficult. One of the rules, for instance, is that once a Pokemon faints, it cannot be revived--yikes.
Pokemon Uranium also comes with online features, which is impressive for a fan-made game. It has its own versions of the Global Trade Station and Wonder Trade, and a way to upload your team so other players can battle a CPU-controller version (you can't face off directly). You can find out more, and download the current build, at the website linked above--be sure to watch the trailer below to see it in action.